Fanconi Anemia Research Fund

Scientific Symposium Poster Presentations October 2003, Houston, Texas
Carcinogenesis Aplasia and Bone Marrow Transplantation Protein Function: DNA Damage and Repair Gene Therapy Cell Signaling Miscellaneous	Researchers discuss posters at the 2003 Scientific Symposium in Houston

Carcinogenesis

Blanche Alter, MD, MPH	National Cancer Institute, Rockville, Maryland	Cancer Epidemiology in Fanconi’s Anemia: Lessons from the IBMFS
Najim Ameziane, MSc	Vrije Universiteit Medical Center, Amsterdam, The Netherlands	Bi-allelic Silencing of the Fanconi Anemia Gene FANCF in an AML Cell
Chris Mathew, PhD	King’s College, London, UK	Haplo-Insufficiency of Fanconi Anaemia Gene LOCI in Cancer
Philip Rosenberg, PhD	National Cancer Institute, Rockville, Maryland	Risk of Squamous Cell Cancer (SCC) and Death in Transplanted and Untransplanted Patients with Fanconi Anemia
Bhuvanesh Singh, MD	Memorial Sloan-Kettering Cancer Center, New York	Molecular Classification of Fanconi Anemia-Associated Head and Neck Squamous Cell Carcinoma (HNSCC) Using Oligonucleotide Microarrays

Aplasia and Bone Marrow Transplantation

Farid Boulad, MD	Memorial Sloan-Kettering Cancer Center, New York	Fanconi Anemia: A Case Report of an Unusual Course
Farid Boulad, MD	Memorial Sloan-Kettering Cancer Center, New York	Secondary Hematopoietic Stem Cell Transplant for Acute Myelogenous Leukemia and Fanconi Anemia Following Cytoreduction with Busulfan, Fludarabine
Nupur Gangopadhyay, DVM, PhD	University of Pittsburgh Cancer Institute, Pennsylvania	Facilitation of Allogenic Bone Marrow Derived Stem Cell Engraftment Utilizing
Yigal Dror, MD	Hospital for Sick Children, Toronto, Canada	The Inherited Marrow Failure Syndromes: Epidemiology and Hematological Abnormalities at Presentation. Reports from the Canadian Inherited Marrow Failure Registry (CIMFR)
Jean-Hugues Dalle, MD	H�pital Sainte-Justine, Montreal, Canada	Successful Pregnancies After Bone Marrow Transplantation in a Fanconi Anemia Patient
Jerome Larghero, PhD	H�pital Sainte-Louis, Paris, France	Stem Cell Clonogenic Capacity in FA Patients is Linked to Somatic Mosaicism
John Wagner, MD	University of Minnesota, Minneapolis, Minnesota	Clinical Impact of Hematopoietic Cell Somatic Mosaicism
Menachem Bitan, MD	Hadassah Hebrew University Hospital, Jerusalem, Israel	The Use of Fludarabine Based Reduced Intensity Conditioning for the Treatment of Patients with Fanconi’s Anemia
Pooneh Heydari, MD	Tehran University of Medical Science, Tehran, Iran	Allogeneic Blood and Marrow Transplantation in Fanconi Anemia: an Experience of Iran

Protein Function: DNA Damage and Repair

Miriam Ferrer, MSc	Vrije University Medical Center, Amsterdam, The Netherlands	Nuclear-Cytoplasmic Shuttling of FANCA: Characterization of Three Novel Nuclear Export Sequences in FANCA
Celine Jacquemont, PhD Student	Institute Curie, Paris, France	Global Cellular Response to Specific DNA Damages of BRCA and FANC Mutated Cells
Nigel Jones, PhD	University of Liverpool, UK	Characterization of FANCG, BRCA2/FANCD1 and RAD51C Protein Interactions Using Chinese Hamster Cell Mutants
Satoru Komaki, MD	Oregon Health and Science University, Portland, Oregon	S-Phase Specific Hyper-Recombination Phenotype in Fanconi Anemia Cells
Muriel Lambert, PhD	New Jersey Medical School, Newark, New Jersey	FANCA and FANCG Interact Directly with Nonerythroid Alpha Spectrin II
Stephen Meyn, MD, FRCP(C)	Hospital for Sick Children, Toronto, Ontario, Canada	FANCD2 Associates with BLM at Telomeres in ALT-Immortalized Human Cells
Dora Papadopoulo, PhD	Institute Curie, Paris, France	Mutations in FANC and BRCA Genes Compromise the Faithful Rejoining of Broken DNA Ends
Jordi Surrall�s, PhD	Universitat Aut�noma de Barcelona, Bellaterra, Spain	No Role of the Fanconi Anaemia Gene FANCD2 in Normal Length Trinucleotide Repeat Instability
Andrei Thomashevski, PhD	University of Virginia, Charlottesville, Virginia	FA Core Complex Exists in 4 Distinct Forms in Different Subcellular Compartments
Weidong Wang, PhD	National Institute on Aging, National Institutes of Health, Baltimore, Maryland	Characterizing a Fanconi Anemia Core Complex
Margaret Zdzienicka, PhD	Leiden University Medical Center, Leiden, The Netherlands	Dissecting of the Cellular Responses to Cross-Linking Agents by Using Mammalian Mutants Sensitive to these Agents
Mark Brenneman, PhD	Rutgers University, Piscataway, New Jersey	BRCA2 (FANC-D1/B) Participates in Homologous Recombinational Repair via Multiple Protein- and DNA-Interacting Domains

Gene Therapy

Francesco Galimi, MD, PhD	The Salk Institute, La Jolla, California	Lentiviral-Mediated Gene Correction of Human Hematopoietic Progenitors from Fanconi Anemia Patients
Peter Kurre, MD	Fred Hutchinson Cancer Research Center, Seattle, Washington	Phenotypic Correction of Murine FANCC Deficient Hematopoietic Cells Using Foamy Virus Vectors
Anuj Mankad, Graduate Student	Oregon Health and Science University, Portland, Oregon	Natural “Embryonic Gene Therapy”: Acquired Secondary Mutation in Monozygotic Twin Sisters with Mutation in FANCA Gives Rise to Corrected Hematopoietic Lineage of Both Sisters
Meenakshi Noll, PhD	Oregon Health and Science University, Portland, Oregon	In Vivo Hematopoietic Stem Cell Selection using Clinically Relevant Drugs in Mouse Model of Fanconi Anemia Group A
Kaoru Yamada, PhD	Mt. Sinai School of Medicine, New York, New York	Retroviral Integration Site Analysis of Fanconi Anemia Patient Samples Following Retroviral-Mediated Gene Transfer

Cell Signaling

Kathryn Leung, MD	Baylor College of Medicine, Houston, Texas	Fanconi Anemia and Oxidative Stress:� The FANCG Protein Interacts with Peroxiredoxin 3
Johnson Liu, MD	Mount Sinai School of Medicine, New York, New York	Fanconi Anemia and Phosphoinositide (PI) / Inositol Phosphate (IP) Signaling Proteins
Filippo Rosselli, PhD	Institut Gustave Roussy, Villejuif, France	TNF-a Overproduction in Fanconi Anemia: Molecular Origins and Consequences
Linda Sandercock, PhD	University of Calgary, Canada	Sensitivity of Murine Fancc-/- Hematopoietic Cells to Nitric Oxide Extends to Human FANCC-/- Lymphoblasts
Robert Tebbs, PhD	Lawrence Livermore National Laboratory, Livermore, California	G2 Phase Delay in Hamster CHO FancG Knockout Cells

Giovanni Pagano, ScD

Italian National Cancer Institute, Mercogliano, Italy

Redox Toxicity Mechanisms Characterize All Xenobiotics Involved in Excess Toxicity to FA Cells

Miscellaneous

Jun Mi, PhD	University of Virginia, Charlottesville, Virginia	FANCG Phosphorylation at Serines 7, 383, and 387
W. Clark Lambert, MD, PhD	New Jersey Medical School, Newark, New Jersey	Correction of the Fanconi Anemia Phenotype at the Cellular Level Using Hydroxyurea: Implications for Etiopathogenesis and Management
Johannes Rischewski, MD	University Hospital Eppendorf, Hamburg, Germany	Mutation Spectrum of FANCC in Europe and DHLPC-Based Identification of a Large Deletion
Akiko Shimamura, MD, PHD	Dana-Farber Cancer Institute, Boston, Massachusetts	Mutational Analysis of the Fanconi Anemia Complementation Group D2 Gene, FANCD2
Jean Soulier, MD, PhD	H�pital Saint-Louis, Paris, France	Analysis of the FANCD2 Pathway in FA Patients: New Diagnosis Tool, Detection of Mosaicism and Subtyping
Stacie Stone, Graduate Student	Oregon Health and Science University, Portland, Oregon	The Fanconi Anemia Pathway is Functionally Conserved in Xenopus
Elsa Call�n Mor�u, PhD Student	Universitat Aut�noma de Barcelona, Spain	Genetic Characterization of Fanconi Anemia in Spanish Gypsies: the Ethnical Group with the Highest Incidence of Fanconi Anemia in the World
Henri van de Vrugt, PhD	Vrije Universiteit, Amsterdam, The Netherlands	Characterization of Murine Fancf
Michael Wallisch, PhD	Oregon Health and Science University, Portland, Oregon	FANCA is Spatially and Temporally Regulated During the Cell Cycle

Fanconi Anemia Research Fund, Inc. Fanconi Anemia Research Fund, Inc.

Menachem Bitan, MD

Pooneh Heydari, MD

Miriam Ferrer, MSc

Celine Jacquemont, PhD Student

Satoru Komaki, MD

Jordi Surrall�s, PhD

Andrei Thomashevski, PhD

Weidong Wang, PhD

Margaret Zdzienicka, PhD

Mark Brenneman, PhD

Johnson Liu, MD

Linda Sandercock, PhD

Robert Tebbs, PhD

Jun Mi, PhD

Johannes Rischewski, MD

Akiko Shimamura, MD, PHD

Jean Soulier, MD, PhD

Stacie Stone, Graduate Student