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Deciphering the endocrine-specific role of FA proteines in pancreas islets

2015 | Research Grant | Nicholas Woods

Since many FA patients also suffer from diabetes and insulin resistance, the research proposed in this application is designed to determine the function of Fanconi anemia proteins in the endocrine pancreas. This study will analyze the dynamic features of FA protein expression and response to glucose…

Identifying the nature of the endogenous aldehydes-induced DNA damage that Fanconi anemia DNA repair pathways counteract

2015 | Research Grant | Rui Yu

All living cells form formaldehyde and acetaldehyde through normal metabolism (also from food and alcohol consumption). However, these aldehydes also induce severe DNA damage, which must be tolerated or repaired to prevent diseases. Currently, ~1 billion people in the world have difficulty in…

The effects of loss of Fanconi gene function on the behavior and therapeutic responses of head and neck cancers

2015 | Research Grant | Ian Mackenzie

In an attempt to explain the high frequency of head and neck cancers in FA patients we have examined differences in the behaviour and signaling pathways of oral epithelial cells (cells that line the oral cavity) lacking Fanconi gene function. Experimental reduction of expression of FA-__A and FA-__C…