A new and rare condition affecting patients with Fanconi anemia has emerged over the last few years. This condition leads to brain lesions which can lead to weakness, seizures and cognitive issues. We do not know the cause of this condition. Current thinking suggests that it may be due to over-activation of the immune system leading the blood vessel abnormalities. We plan to closely examine the immune profile in these patients to try and find the underlying cause and find an appropriate therapy.