Supported Research

Targeting LNK(SH2B3) to ameliorate hematopoietic stem/progenitor defects in Fanconi Anemia

2016 | Children's Hospital of Philadelphia | Research Grant

Amount Funded: $204,593

Dr. Tong recently discovered a novel gene called “LNK” that regulates bone marrow cell survival and growth. She found that loss of LNK in a mouse model of FA restores normal bone marrow functions and increases stem cell longevity. This new grant will allow Dr. Tong to explore the mechanisms underlying this important discovery and to develop new strategies to inhibit LNK to improve bone marrow function in Fanconi anemia. This work will also advance efforts to correct Fanconi mutations by gene therapy.

Researchers: Wei Tong